Using iLINCS to mine for Oxytocin signature to find new drug candidates or molecular pathways that can be used for future treatment for autism
DOI:
https://doi.org/10.46570/utjms-2025-1486Keywords:
Autism, ASD, aspergers, Oxytocin, psychoneuroendocrinologyReferences
Andari E, Duhamel JR, Zalla T, Herbrecht E, Leboyer M, Sirigu A. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci U A. 2010;107(9):4389-4394. doi:10.1073/pnas.0910249107 DOI: https://doi.org/10.1073/pnas.0910249107
Guastella AJ, Hickie IB. Oxytocin Treatment, Circuitry, and Autism: A Critical Review of the Literature Placing Oxytocin Into the Autism Context. Biol Psychiatry. 2016;79(3):234-242. doi:10.1016/j.biopsych.2015.06.028 DOI: https://doi.org/10.1016/j.biopsych.2015.06.028
Young LJ, Wang Z. The neurobiology of pair bonding. Nat Neurosci. 2004;7(10):1048-1054. doi:10.1038/nn1327 DOI: https://doi.org/10.1038/nn1327
Janz P, Knoflach F, Bleicher K, et al. Selective oxytocin receptor activation prevents prefrontal circuit dysfunction and social behavioral alterations in response to chronic prefrontal cortex activation in male rats. Front Cell Neurosci. 2023;17:1286552. doi:10.3389/fncel.2023.1286552 DOI: https://doi.org/10.3389/fncel.2023.1286552
Nishimura H, Yoshimura M, Shimizu M, et al. Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats. Commun Biol. 2022;5(1):907. doi:10.1038/s42003-022-03879-8 DOI: https://doi.org/10.1038/s42003-022-03879-8
Wasserman AH, Huang AR, Lewis-Israeli YR, et al. Oxytocin promotes epicardial cell activation and heart regeneration after cardiac injury. Front Cell Dev Biol. 2022;10:985298. doi:10.3389/fcell.2022.985298 DOI: https://doi.org/10.3389/fcell.2022.985298
Xie Z, Kropiwnicki E, Wojciechowicz ML, et al. Getting Started with LINCS Datasets and Tools. Curr Protoc. 2022;2(7):e487. doi:10.1002/cpz1.487 DOI: https://doi.org/10.1002/cpz1.487
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Gabby, Elissar Andari (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
